Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Table 2

The comparative wound healing efficiency (wound area and % wound closure) of ointment formulation (F1 and F2) and pure drug in diabetic and nondiabetic wound of albino rats.

Days	Wound parameters	Control group		F1 (5%)		Chloramphenicol sodium		F2 (10%)
		DW	Non-DW	DW	Non-DW	DW	Non-DW	DW	Non-DW
0	Wound area	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00	317.21 ± 0.00
	% wound closure	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
3^rd	Wound area	276.91 ± 17.71	267.11 ± 12.71	267.22 ± 12.70	267.23 ± 13.69	276.91 ± 12.17	267.27 ± 19.74	267.12 ± 12.18	267.23 ± 11.27
	% wound closure	15.81 ± 6.31	18.71 ± 7.32	18.89 ± 6.13	18.82 ± 4.31	15.53 ± 3.33	18.29 ± 7.23	16.71 ± 3.73	18.90 ± 7.23
6^th	Wound area	248.30 ± 18.82	239.21 ± 14.82	221.41 ± 12.98	221.34 ± 12.79	212.27 ± 18.19	212.67 ± 11.59	221.41 ± 12.19	187.89 ± 17.09
	% wound closure	24.49 ± 7.06	27.81 ± 4.08	33.45 ± 5.72	33.52 ± 1.72	36.21 ± 6.71	36.21 ± 3.66	33.55 ± 6.37	44.19 ± 3.41
9^th	Wound area	212.67 ± 18.29	164.52 ± 14.11	172.21 ± 11.19	172.21 ± 11.10	164.23 ± 17.11	122.61 ± 10.53	172.31 ± 09.14	122.66 ± 14.44
	% wound closure	36.21 ± 8.71	51.52 ± 7.23	49.12 ± 6.21	49.13 ± 5.18	51.52 ± 7.12	64.89 ± 2.52	49.11 ± 7.31	64.82 ± 7.62
12^th	Wound area	164.52 ± 13.15	122.62 ± 13.31	122.62 ± 10.53	122.56 ± 12.31	122.60 ± 10.43	87.09 ± 8.55	98.51 ± 12.32	57.72 ± 8.81
	% wound closure	51.58 ± 5.19	64.91 ± 5.63	64.91 ± 4.61	64.89 ± 4.61	64.89 ± 7.76	76.22 ± 5.13	72.51 ± 8.51	85.55 ± 3.54
15^th	Wound area	119.09 ± 11.34	68.62 ± 8.62	84.07 ± 9.53	84.07 ± 9.53	54.73 ± 7.71	59.19 ± 7.71	54.73 ± 7.71	31.69 ± 5.89
	% wound closure	64.19 ± 5.06	81.71 ± 3.47	76.52 ± 2.30	76.52 ± 6.31	85.51 ± 4.14	84.2 ± 4.53	85.51 ± 4.64	92.97 ± 3.78
18^th	Wound area	87.72 ± 8.51	45.41 ± 4.81	58.21 ± 12.59	45.42 ± 8.81	34.79 ± 7.89	28.41 ± 6.89	5.67 ± 8.86	3.87 ± 3.64
	% wound closure	76.21 ± 4.33	89.51 ± 5.76	85.42 ± 6.62	89.51 ± 4.17	92.91 ± 3.82	94.97 ± 3.51	96.21 ± 0.43	96.51 ± 1.14
21^th	Wound area	62.18 ± 8.61	34.39 ± 3.18	28.42 ± 5.91	16.10 ± 4.31	5.91 ± 6.12	3.51 ± 1.33	1.92 ± 2.11	2.15 ± 1.23
	% wound closure	83.11 ± 3.41	88.91 ± 1.82	93.91 ± 1.65	96.81 ± 2.04	99.81 ± 3.16	99.15 ± 1.41	99.12 ± 5.21	98.13 ± 1.14
Endpoint of complete epithelization		29.31 ± 0.37	33.32 ± 1.43	28.61 ± 2.41	25.12 ± 1.81	26.61 ± 2.54	23 ± 2.81	20.13 ± 3.41	18.61 ± 4.44