Huayu Jiedu Fang Protects Ovarian Function in Mouse with Endometriosis Iron Overload by Inhibiting Ferroptosis

Figure 1

| The flow chart of iron-overload model mouse construction and HYJDF treatment of EM. First, an iron-overload model of EM mouse was constructed based on periodic intraperitoneal blood administration to demonstrate that ferroptosis plays a role in EM. In the second step, HYJDF was shown to inhibit ferroptosis to treat EM and improve ovarian function. Finally, plasmapheresis and network pharmacology were applied to investigate the core components in HYJDF and the specific mechanism of ferroptosis inhibition.