Action Mechanism Underlying Improvement Effect of Fuzi Lizhong Decoction on Nonalcoholic Fatty Liver Disease: A Study Based on Network Pharmacology and Molecular Docking

Table 1

Active compounds of FLD in NAFLD treatment.

Molecule ID	Molecule name	OB (%)	DL (%)	Source
MOL002211	11,14-Eicosadienoic acid	39.99	0.2	FZ1
MOL002388	Delphin_qt	57.76	0.28	FZ2
MOL002392	Deltoin	46.69	0.37	FZ3
MOL002393	Demethyldelavaine A	34.52	0.18	FZ4
MOL002394	Demethyldelavaine B	34.52	0.18	FZ5
MOL002395	Deoxyandrographolide	56.3	0.31	FZ6
MOL002397	Karakoline	51.73	0.73	FZ7
MOL002398	Karanjin	69.56	0.34	FZ8
MOL002401	Neokadsuranic acid B	43.1	0.85	FZ9
MOL002406	2,7-Dideacetyl-2,7-dibenzoyl-taxayunnanine F	39.43	0.38	FZ10
MOL002410	Benzoylnapelline	34.06	0.53	FZ11
MOL002415	6-Demethyldesoline	51.87	0.66	FZ12
MOL002416	Deoxyaconitine	30.96	0.24	FZ13
MOL002419	(R)-Norcoclaurine	82.54	0.21	FZ14
MOL002421	Ignavine	84.08	0.25	FZ15
MOL002422	Isotalatizidine	50.82	0.73	FZ16
MOL002423	Jesaconitine	33.41	0.19	FZ17
MOL002433	(3R,8S,9R,10 R,13R,14S,17R)-3-Hydroxy-4,4,9,13,14-pentamethyl-17-[(E,2R)-6-methyl-7-[(2R,3 R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3 R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhept-5-en-2-yl]-1,2,3,7,8,10,12,15,16,17-decahydr	41.52	0.22	FZ18
MOL002434	Carnosifloside I_qt	38.16	0.8	FZ19
MOL000359	Sitosterol	36.91	0.75	FZ20
MOL000538	Hypaconitine	31.39	0.26	FZ21
MOL002464	1-Monolinolein	37.18	0.3	GJ1
MOL002501	[(1S)-3-[(E)-but-2-enyl]-2-Methyl-4-oxo-1-cyclopent-2-enyl] (1r,3 R)-3-[(E)-3-methoxy-2-methyl-3-oxoprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate	62.52	0.31	GJ2
MOL002514	Sexangularetin	62.86	0.3	GJ3
MOL000358	Beta-sitosterol	36.91	0.75	GJ4
MOL000359	Sitosterol	36.91	0.75	GJ5
MOL000020	12-Senecioyl-2E,8 E,10E-atractylentriol	62.4	0.22	BZ1
MOL000021	14-Acetyl-12-senecioyl-2E,8 E,10E-atractylentriol	60.31	0.31	BZ2
MOL000022	14-Acetyl-12-senecioyl-2E,8Z,10E-atractylentriol	63.37	0.3	BZ3
MOL000028	α-Amyrin	39.51	0.76	BZ4
MOL000033	(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol	36.23	0.78	BZ5
MOL000049	3β-Acetoxyatractylone	54.07	0.22	BZ6
MOL000072	8β-Ethoxy atractylenolide III	35.95	0.21	BZ7
MOL002879	Diop	43.59	0.39	RS1
MOL000449	Stigmasterol	43.83	0.76	RS2
MOL000358	Beta-sitosterol	36.91	0.75	RS3
MOL003648	Inermin	65.83	0.54	RS4
MOL000422	Kaempferol	41.88	0.24	RS5
MOL004492	Chrysanthemaxanthin	38.72	0.58	RS6
MOL005308	Aposiopolamine	66.65	0.22	RS7
MOL005314	Celabenzine	101.88	0.49	RS8
MOL005317	Deoxyharringtonine	39.27	0.81	RS9
MOL005318	Dianthramine	40.45	0.2	RS10
MOL005320	Arachidonate	45.57	0.2	RS11
MOL005321	Frutinone A	65.9	0.34	RS12
MOL005344	Ginsenoside rh2	36.32	0.56	RS13
MOL005348	Ginsenoside-Rh4_qt	31.11	0.78	RS14
MOL005356	Girinimbin	61.22	0.31	RS15
MOL005357	Gomisin B	31.99	0.83	RS16
MOL005360	Malkangunin	57.71	0.63	RS17
MOL005376	Panaxadiol	33.09	0.79	RS18
MOL005384	Suchilactone	57.52	0.56	RS19
MOL005399	Alexandrin_qt	36.91	0.75	RS20
MOL005401	Ginsenoside Rg5_qt	39.56	0.79	RS21
MOL000787	Fumarine	59.26	0.83	RS22
MOL001484	Inermine	75.18	0.54	GC1
MOL001792	DFV	32.76	0.18	GC2
MOL000211	Mairin	55.38	0.78	GC3
MOL002311	Glycyrol	90.78	0.67	GC4
MOL000239	Jaranol	50.83	0.29	GC5
MOL002565	Medicarpin	49.22	0.34	GC6
MOL000354	Isorhamnetin	49.6	0.31	GC7
MOL000359	Sitosterol	36.91	0.75	GC8
MOL003656	Lupiwighteone	51.64	0.37	GC9
MOL003896	7-Methoxy-2-methyl isoflavone	42.56	0.2	GC10
MOL000392	Formononetin	69.67	0.21	GC11
MOL000417	Calycosin	47.75	0.24	GC12
MOL000422	Kaempferol	41.88	0.24	GC13
MOL004328	Naringenin	59.29	0.21	GC14
MOL004805	(2S)-2-[4-Hydroxy-3-(3-methylbut-2-enyl)phenyl]-8,8-dimethyl-2,3-dihydropyrano[2,3-f]chromen-4-one	31.79	0.72	GC15
MOL004806	Euchrenone	30.29	0.57	GC16
MOL004808	Glyasperin B	65.22	0.44	GC17
MOL004810	Glyasperin F	75.84	0.54	GC18
MOL004811	Glyasperin C	45.56	0.4	GC19
MOL004814	Isotrifoliol	31.94	0.42	GC20
MOL004815	(E)-1-(2,4-Dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one	39.62	0.35	GC21
MOL004820	Kanzonols W	50.48	0.52	GC22
MOL004824	(2S)-6-(2,4-Dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	60.25	0.63	GC23
MOL004827	Semilicoisoflavone B	48.78	0.55	GC24
MOL004828	Glepidotin A	44.72	0.35	GC25
MOL004829	Glepidotin B	64.46	0.34	GC26
MOL004833	Phaseolinisoflavan	32.01	0.45	GC27
MOL004835	Glypallichalcone	61.6	0.19	GC28
MOL004838	8-(6-Hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol	58.44	0.38	GC29
MOL004841	Licochalcone B	76.76	0.19	GC30
MOL004848	Licochalcone G	49.25	0.32	GC31
MOL004849	3-(2,4-Dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin	59.62	0.43	GC32
MOL004855	Licoricone	63.58	0.47	GC33
MOL004856	Gancaonin A	51.08	0.4	GC34
MOL004857	Gancaonin B	48.79	0.45	GC35
MOL004860	Licorice glycoside E	32.89	0.27	GC36
MOL004863	3-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromone	66.37	0.41	GC37
MOL004864	5,7-Dihydroxy-3-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromone	30.49	0.41	GC38
MOL004866	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromone	44.15	0.41	GC39
MOL004879	Glycyrin	52.61	0.47	GC40
MOL004882	Licocoumarone	33.21	0.36	GC41
MOL004883	Licoisoflavone	41.61	0.42	GC42
MOL004884	Licoisoflavone B	38.93	0.55	GC43
MOL004885	Licoisoflavanone	52.47	0.54	GC44
MOL004891	Shinpterocarpin	80.3	0.73	GC45
MOL004898	(E)-3-[3,4-Dihydroxy-5-(3-methylbut-2-enyl)phenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one	46.27	0.31	GC46
MOL004903	Liquiritin	65.69	0.74	GC47
MOL004904	Licopyranocoumarin	80.36	0.65	GC48
MOL004905	3,22-Dihydroxy-11-oxo-delta(12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid	34.32	0.55	GC49
MOL004907	Glyzaglabrin	61.07	0.35	GC50
MOL004908	Glabridin	53.25	0.47	GC51
MOL004910	Glabranin	52.9	0.31	GC52
MOL004911	Glabrene	46.27	0.44	GC53
MOL004912	Glabrone	52.51	0.5	GC54
MOL004913	1,3-Dihydroxy-9-methoxy-6-benzofurano [3,2-c]chromenone	48.14	0.43	GC55
MOL004914	1,3-Dihydroxy-8,9-dimethoxy-6-benzofurano [3,2-c]chromenone	62.9	0.53	GC56
MOL004915	Eurycarpin A	43.28	0.37	GC57
MOL004917	Glycyroside	37.25	0.79	GC58
MOL004924	(-)-Medicocarpin	40.99	0.95	GC59
MOL004935	Sigmoidin-B	34.88	0.41	GC60
MOL004941	(2R)-7-Hydroxy-2-(4-hydroxyphenyl)chroman-4-one	71.12	0.18	GC61
MOL004945	(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one	36.57	0.32	GC62
MOL004948	Isoglycyrol	44.7	0.84	GC63
MOL004949	Isolicoflavonol	45.17	0.42	GC64
MOL004957	HMO	38.37	0.21	GC65
MOL004959	1-Methoxyphaseollidin	69.98	0.64	GC66
MOL004961	Quercetin der.	46.45	0.33	GC67
MOL004966	3'-Hydroxy-4'-O-Methylglabridin	43.71	0.57	GC68
MOL000497	Licochalcone a	40.79	0.29	GC69
MOL004974	3'-Methoxyglabridin	46.16	0.57	GC70
MOL004978	2-[(3R)-8,8-Dimethyl-3,4-dihydro-2h-pyrano [6,5-f]chromen-3-yl]-5-methoxyphenol	36.21	0.52	GC71
MOL004980	Inflacoumarin A	39.71	0.33	GC72
MOL004985	Icos-5-enoic acid	30.7	0.2	GC73
MOL004988	Kanzonol F	32.47	0.89	GC74
MOL004989	6-Prenylated eriodictyol	39.22	0.41	GC75
MOL004990	7,2',4'-Trihydroxy－5-methoxy-3－arylcoumarin	83.71	0.27	GC76
MOL004991	7-Acetoxy-2-methylisoflavone	38.92	0.26	GC77
MOL004993	8-Prenylated eriodictyol	53.79	0.4	GC78
MOL004996	Gadelaidic acid	30.7	0.2	GC79
MOL000500	Vestitol	74.66	0.21	GC80
MOL005000	Gancaonin G	60.44	0.39	GC81
MOL005001	Gancaonin H	50.1	0.78	GC82
MOL005003	Licoagrocarpin	58.81	0.58	GC83
MOL005007	Glyasperins M	72.67	0.59	GC84
MOL005008	Glycyrrhiza flavonol A	41.28	0.6	GC85
MOL005012	Licoagroisoflavone	57.28	0.49	GC86
MOL005013	18α-Hydroxyglycyrrhetic acid	41.16	0.71	GC87
MOL005016	Odoratin	49.95	0.3	GC88
MOL005017	Phaseol	78.77	0.58	GC89
MOL005018	Xambioona	54.85	0.87	GC90
MOL005020	Dehydroglyasperins C	53.82	0.37	GC91
MOL000098	Quercetin	46.43	0.28	GC92
MOL000359	Sitosterol	36.91	0.75	FZ20, Gj5, GC8 (A1)
MOL000358	Beta-sitosterol	36.91	0.75	GJ4, RS3(B1)
MOL000422	Kaempferol	41.88	0.24	RS5,GC13(C1)