Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts
Table 1
Summary of scores for arthritis, paw edema, and histological parameters.
Vehicle control
Arthritic control
Piroxicam
EEJR
NHJR
AS at day 8
0.000 ± 0.000
3.083 ± 0.083
3.083 ± 0.083
3.000 ± 0.083
3.083 ± 0.083
AS at day 15
0.000 ± 0.000
3.417 ± 0.017
2.417 ± 0.083
2.583 ± 0.083
2.833 ± 0.105
AS at day 22
0.000 ± 0.000
3.417 ± 0.034
2.417 ± 0.083
2.083 ± 0.083
2.500 ± 0.129
AS at day 28
0.000 ± 0.000
3.917 ± 0.078
2.083 ± 0.083
1.917 ± 0.083
2.250 ± 0.112
PE at day 8
0.000 ± 0.000
0.942 ± 0.013
0.960 ± 0.013
0.950 ± 0.004
0.943 ± 0.008
PE at day 15
0.000 ± 0.000
1.144 ± 0.017
0.783 ± 0.008
0.788 ± 0.010
0.883 ± 0.006
PE at day 22
0.000 ± 0.000
1.242 ± 0.012
0.718 ± 0.007
0.753 ± 0.011
0.744 ± 0.011
PE at day 28
0.000 ± 0.000
1.366 ± 0.009
0.627 ± 0.008
0.647 ± 0.010
0.688 ± 0.018
HP-INF
0.000 ± 0.000
2.583 ± 0.083
1.583 ± 0.083
1.833 ± 0.105
2.167 ± 0.083
HP-PF
0.000 ± 0.000
3.417 ± 0.083
2.333 ± 0.105
2.583 ± 0.083
2.667 ± 0.105
HP-BE
0.000 ± 0.000
2.583 ± 0.083
2.083 ± 0.083
2.083 ± 0.083
2.167 ± 0.0.105
AS, arthritis score; PE, paw edema; HP, histological parameter; INF, inflammation; PF, pannus formation; BE, bone erosion. Scores are mean ± SEM; ,, and .
