Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts
Table 4
Evaluation of hematological and biochemical parameters in the arthritic rats.
Blood parameters
Vehicle control, mean ± SEM
Arthritis control, mean ± SEM
Piroxicam, mean ± SEM
EEJR, mean ± SEM
NHJR, mean ± SEM
RBC (106/Ul)
8.3 ± 0.3
5.6 ± 0.3###
7.5 ± 0.3
7.280 ± 0.2
7.4 ± 0.1
Hb (g/dl)
14.8 ± 0.1
11.7 ± 0.2###
13.6 ± 0.2
13.97 ± 0.4
13.4 ± 0.1
WBC (103/Ul)
10 ± 0.3
15.1 ± 0.3###
12.9 ± 0.2
12.88 ± 0.2
12.5 ± 0.4
Platelets (103/Ul)
798.7 ± 27.8
1444 ± 18.4###
1044 ± 32.7
937.2 ± 13.3
1163 ± 41.3
Urea (mg/dl)
26.3 ± 0.6
27.8 ± 0.9
26.1 ± 0.4
27.33 ± 0.3
26.3 ± 0.2
Creatinine (mg/dl)
0.8 ± 0.2
0.9 ± 0.01
0.8 ± 0.02
0.800 ± 0.02
0.8 ± 0.02
AST (IU/L)
96.7 ± 1.7
98.8 ± 1.5
94.7 ± 1.2
95.4 ± 1.7
95.5 ± 1.2
ALT (IU/L)
30.3 ± 0.5
31.8 ± 0.5
33.6 ± 0.4
33.1 ± 0.9
33.8 ± 0.7
EEJR, ethanolic extract of J. regia (500 mg/kg); NHJR, n-hexane extract of J. regia (500 mg/kg); piroxicam (10 mg/kg). RBC, red blood cell; Hb, hemoglobin; WBC, white blood cell; AST, aspartate transaminase; ALT, alanine aminotransferase. ,, and as compared with the arthritic control group.