Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts

Table 4

Evaluation of hematological and biochemical parameters in the arthritic rats.

Blood parameters	Vehicle control, mean ± SEM	Arthritis control, mean ± SEM	Piroxicam, mean ± SEM	EEJR, mean ± SEM	NHJR, mean ± SEM
RBC (10^6/Ul)	8.3 ± 0.3	5.6 ± 0.3^###	7.5 ± 0.3	7.280 ± 0.2	7.4 ± 0.1
Hb (g/dl)	14.8 ± 0.1	11.7 ± 0.2^###	13.6 ± 0.2	13.97 ± 0.4	13.4 ± 0.1
WBC (10^3/Ul)	10 ± 0.3	15.1 ± 0.3^###	12.9 ± 0.2	12.88 ± 0.2	12.5 ± 0.4
Platelets (10^3/Ul)	798.7 ± 27.8	1444 ± 18.4^###	1044 ± 32.7	937.2 ± 13.3	1163 ± 41.3
Urea (mg/dl)	26.3 ± 0.6	27.8 ± 0.9	26.1 ± 0.4	27.33 ± 0.3	26.3 ± 0.2
Creatinine (mg/dl)	0.8 ± 0.2	0.9 ± 0.01	0.8 ± 0.02	0.800 ± 0.02	0.8 ± 0.02
AST (IU/L)	96.7 ± 1.7	98.8 ± 1.5	94.7 ± 1.2	95.4 ± 1.7	95.5 ± 1.2
ALT (IU/L)	30.3 ± 0.5	31.8 ± 0.5	33.6 ± 0.4	33.1 ± 0.9	33.8 ± 0.7

EEJR, ethanolic extract of J. regia (500 mg/kg); NHJR, n-hexane extract of J. regia (500 mg/kg); piroxicam (10 mg/kg). RBC, red blood cell; Hb, hemoglobin; WBC, white blood cell; AST, aspartate transaminase; ALT, alanine aminotransferase. , , and as compared with the arthritic control group.