Research Article

Suhuang Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway

Figure 9

The graphic illustration of the antitussive mechanism of Suhuang. Suhuang increased expression of GR in a manner dependent on inhibition of p38 MAPK phosphorylation and activity by increasing MKP-1 level. Therefore, combination treatment of Suhuang and BUD showed better improvement in AHR, cough symptom, histopathological changes, and inflammatory cytokines production.