Research Article
Suhuang Antitussive Capsule Ameliorates Corticosteroid Insensitivity in Cough Variant Asthma Guinea Pigs by Inhibiting p38 MAPK Signal Pathway
| Grade of fibrosis | Manifestations |
| 0 | Alveolar septa: no fibrotic burden at the most flimsy small fibres in some alveolar walls | Lung structure: normal lung | 1 | Alveolar septa: isolated gentle fibrotic changes (septum <3× thicker than normal) | Lung structure: alveoli partly enlarged and rarefield, but no fibrotic masses present | 2 | Alveolar septa: clearly fibrotic changes (septum >3× thicker than normal) with knot like formation but not connected to each other | Lung structure: alveoli partly enlarged and rarefield, but no fibrotic masses present | 3 | Alveolar septa: contiguous fibrotic walls (septum >3× thicker than normal) predominantly in whole microscopic field | Lung structure: alveoli partly enlarged and rarefield, but no fibrotic masses present | 4 | Alveolar septa: variable | Lung structure: single fibrotic masses (<10% microscopic field) | 5 | Alveolar septa: variable | Lung structure: single fibrotic masses (>10% and <50% microscopic field). Lung structure severely damaged but still preserved | 6 | Alveolar septa: variable, mostly not existent | Lung structure: large contiguous fibrotic masses (>50% microscopic field). Lung structure mostly not preserved | 7 | Alveolar septa: nonexistent | Lung structure: alveoli nearly obliterated with fibrous masses but still up to five air bubbles | 8 | Alveolar septa: nonexistent | Lung structure: microscopic field with complete obliteration with fibrotic masses |
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