Tridax procumbens Ameliorates Streptozotocin-Induced Diabetic Neuropathy in Rats via Modulating Angiogenic, Inflammatory, and Oxidative Pathways

Table 10

Impact of TP on the thermal hyperalgesia in tail flick technique to appraise the neuropathic pain in Wistar rats.

	0 Week	1 Week	2 Week	3 Week	4 Week
Normal control	6.29 ± 0.21	6.49 ± 1.33	5.91 ± 1.24	5.69 ± 0.99	6.55 ± 1.42
Disease control	6.56 ± 2.51	5.35 ± 1.35^#	4.44 ± 1.25^##	4.01 ± 1.92^##	3.31 ± 1.52^##
Standard (Gabapentin)	6.51 ± 1.05	5.48 ± 1.1	5.64 ± 1.51	5.91 ± 1.11	6.42 ± 1.41
TP 250 mg/kg	6.46 ± 1.08	5.38 ± 1.63^a	5.45 ± 1.11^,a	5.64 ± 1.53^,a	5.98 ± 1.62^##,^,aa
TP 375 mg/kg	6.67 ± 1.21	5.41 ± 1.76^,a	5.56 ± 1.39^,aa	5.71 ± 2.09^,a	6.28 ± 1.82^##,^,a
TP 500 mg/kg	6.36 ± 1.51	5.42 ± 1.43	5.68 ± 1.86^,a	5.83 ± 1.68	6.39 ± 1.74
TP 500 mg + Gabapentin	6.59 ± 1.51	5.58 ± 1.55^,b	5.69 ± 1.82^,b	5.89 ± 1.42^,b	6.44 ± 1.68^,b