Tridax procumbens Ameliorates Streptozotocin-Induced Diabetic Neuropathy in Rats via Modulating Angiogenic, Inflammatory, and Oxidative Pathways

Table 5

Impact of TP on endogenous angiogenic and inflammatory biomarkers in rats.

Groups	PKC (ng/ml)	VEGF (pg/ml)	IL-1β (pg/ml)	TNF-α (pg/ml)
Normal control	21.80 ± 1.9	5.670 ± 0.26	23.16 ± 1.21	2.04 ± 0.23
Disease control	76.73 ± 4.81^###	11.69 ± 0.73^###	47.85 ± 4.31^##	5.70 ± 0.52^###
Standard (Gabapentin)	22.87 ± 1.97	6.710 ± 0.84	24.09 ± 1.73	2.59 ± 0.31
TP per se	22.03 ± 1.42	5.902 ± 0.47	26.26 ± 1.88	2.39 ± 0.25
TP 250 mg	36.46 ± 1.97^##,^,a	8.970 ± 0.52^#,aaa	35.40 ± 2.06^##,aa	3.76 ± 0.71^##,a
TP 375 mg	31.46 ± 1.97^#,^,a,b	8.193 ± 0.28^#,^,aa,b	31.61 ± 1.38^#,^,aa,b	3.29 ± 0.28^#,^,b
TP 500 mg	25.94 ± 2.16^,bb,c	7.165 ± 0.51^,b,c	24.93 ± 1.46^,bb,c	2.53 ± 0.24^,b
TP 500 mg + gabapentin	24.01 ± 1.56^,bb,c	6.877 ± 0.12^,bb,cc	23.24 ± 0.84^,bb,c	2.19 ± 0.12^,b,c