Tridax procumbens Ameliorates Streptozotocin-Induced Diabetic Neuropathy in Rats via Modulating Angiogenic, Inflammatory, and Oxidative Pathways

Table 8

Impact of TP on Thermal Hyperalgesia: Eddy’s hot plate test to assess diabetic neuropathy in Wistar albino rats.

	0 Week	1 Week	2 Week	3 Week	4 Week
Normal control	4.29 ± 0.21	4.43 ± 0.051	4.63 ± 1.22	4.64 ± 1.82	4.45 ± 0.51
Disease control	4.5 ± 0.51	5.99 ± 1.71	6.68 ± 1.14	7.69 ± 1.81	9.73 ± 1.52^##
Standard (Gabapentin)	4.92 ± 1.1	5.53 ± 1.01	5.16 ± 2.51	4.99 ± 1.01	4.63 ± 1.52
TP 250 mg/kg	4.92 ± 1.11	5.96 ± 1.63^a	6.63 ± 1.61^,a	6.36 ± 0.51^,a	6.28 ± 0.65^##,^,aa
TP 375 mg/kg	4.82 ± 1.73	5.96 ± 1.61^,a	5.74 ± 2.09^,aa	5.34 ± 1.81^,a	5.14 ± 1.23^##,^,a
TP 500 mg/kg	4.88 ± 1.51	5.54 ± 0.5	5.38 ± 1.76^,a	5.11 ± 1.56	4.88 ± 0.23
TP 500 mg + Gabapentin	4.94 ± 1.71	5.45 ± 1.34^,bb	5.22 ± 1.21^,bb	5.12 ± 0.92^,b	4.56 ± 0.78^,bb