Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against Klebsiella pneumoniae Isolates

Table 1

MIC and MBC (µg/mL) of Thy-NPs and free thymol against planktonic cells of K. pneumoniae.

Isolates	Thymol		Thy-NPs				Empty NPs
	MIC	MBC	MIC	MBC	R1	R2	MIC	MBC
Kp02	128	256	4	16	32	16	>1024	>1024
Kp03	64	512	1	4	64	128	>1024	>1024
Kp04	128	256	8	32	16	8	>1024	>1024
Kp05	256	512	8	16	32	32	>1024	>1024
Kp55	128	512	2	8	16	64	>1024	>1024

MIC: minimum inhibitory concentration, MBC: minimum bactericidal concentration, data from the previous study [10], Thy-NPs: thymol loaded-PLGA nanoparticles, Empty NPs: empty PLGA nanoparticles, R1: MIC of Thy-NPs/MIC of free thymol, and R2: MBC of Thy-NPs/MBC of free thymol.