Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against Klebsiella pneumoniae Isolates

Table 2

MBIC and FICI of combined Thy-NPs with streptomycin against inhibition of biofilm formation of K. pneumoniae.

Isolates	MBIC (µg/mL)			FICI/Int	Fold reduction
	Alone		Combined
	Strep^#	Thy-NPs	Strep + Thy-NPs		Strep	Thy-NPs
Kp02	4	32	0. 125 + 8	0.28/S	32-fold	4-fold
Kp03	4	16	0.0625 + 2	0.14/S	64-fold	8-fold
Kp04	4	64	0.125 + 8	0.16/S	32-fold	8-fold
Kp05	8	32	0.0625 + 4	0.13/S	128-fold	4-fold
Kp55	8	16	0.0625 + 4	0.26/S	128-fold	4-fold

MBIC: minimal biofilm inhibitory concentration, FICI: fractional inhibitory concentration index, Int: interpretation, Strep: streptomycin, Thy-NPs: thymol-loaded PLGA nanoparticles, Strep^#: data from the previous study [10], and S: synergy.