Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against Klebsiella pneumoniae Isolates

Table 3

MBEC and FICI combined Thy-NPs with streptomycin against the eradication of biofilm of K. pneumoniae.

Isolates	MBEC (µg/mL)			FICI/Int	Fold reduction
	Alone		Combined
	Strep^#	Thy-NPs	Strep + Thy-NPs		Strep	Thy-NPs
Kp02	32	128	0.25 + 16	0.13/S	128-fold	8-fold
Kp03	64	32	2 + 8	0.28/S	32-fold	4-fold
Kp04	64	64	1 + 16	0.27/S	64-fold	4-fold
Kp05	128	64	2 + 8	0.14/S	64-fold	8-fold
Kp55	32	128	0.25 + 16	0.13/S	128-fold	8-fold

MBEC: minimal biofilm eradication concentration, FICI: fractional inhibitory concentration index, Int: interpretation, Strep: streptomycin, Thy-NPs: thymol loaded-PLGA nanoparticles, Strep^#: data from the previous study [10], and S: synergy.