Pharmacological Effects of Hydrocotyle bonariensis Comm. ex Lam (Araliaceae) Extract on Cardiac Activity

Figure 4

Effects of H. bonariensis extract on human cardiac sodium current I Nav1.5. Comparison of the amplitudes of cardiac sodium currents recorded on HEK 293-I Nav1.5 cells in control and 0.5 mg/kg H. bonariensisextract-treated conditions ((a) t-test + Mann–Whitney test). The effect of H. bonariensis extract on the current-voltage relationship of the I Nav1.5 channel was estimated by normalizing the current values plotted against the test potential in the absence and presence of the extract ((b) ANOVA+ Sidak’s multiple comparisons test). No change in I Nav1.5 current is observed in the presence of the extract. n = 10.