Pharmacological Effects of Hydrocotyle bonariensis Comm. ex Lam (Araliaceae) Extract on Cardiac Activity

Table 1

Effects of hydroethanolic extract of H. bonariensis leaves on the ECG of Wistar rats.

	P wave (%)	QRS wave (%)	T wave (%)	RR interval (%)	QT interval (%)	Heart rate (%)
Control	100	100	100	100	100	100
HB 10 mg/kg	99,65	92,14	103,72	118,47	110,58	80,48
HB 20 mg/kg	106,88	95,44	91,18	133,85	105,74	72,47
HB 40 mg/kg	98,98	88,77	93,87	131,54	111,50	66,77
HB 80 mg/kg	70,93	95,22	58,46	152,23	104,32	49,02

The amplitudes of the P, QRS, and T waves, the duration of the RR interval, and then the heart rate were analyzed. Infusion of the extract caused a significant decrease in P wave and T wave at 80 mg/kg and then heart rate and a significant increase in RR interval at 20, 40, and 80 mg/kg. n = 4. ; ; ; (2-way ANOVA+ Kruskal–Wallis test). HR: heart rate; HB: Hydrocotyle bonariensis.