Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
Table 1
Baseline values and changes after four weeks of treatment with DS in thirst scores, serum calcium, sodium, potassium, triglycerides, cholesterol, and total antioxidant capacity of the patients at the end of each treatment period in the crossover trial.
Variables
Group I (DS administration followed by placebo)
Group II (placebo followed by DS administration)
Baseline
Change after six weeks
value
Baseline
Change after six weeks
value
Thirst VAS
9.7 ± 0.2
6.6 ± 1.6
0.0001
9.6 ± 0.3
9.4 ± 0.4
0.038
Calcium (mg/dl)
8.2 ± 0.6
7.8 ± 0.77
0.046
7.8 ± 0.6
8.5 ± 0.6
0.0001
Sodium (mEq/L)
136 ± 4.2
136 ± 2.1
0.99
145 ± 6.4
136 ± 3.5
0.0001
Potassium (mEq/L)
5.7 ± 0.89
5.5 ± 0.61
0.34
5.6 ± 0.85
5.8 ± 0.89
0.39
Triglycerides (mg/dl)
193 ± 38
187 ± 43
0.60
210 ± 43
200 ± 39
0.36
Cholesterol (mg/dl)
155 ± 49
149 ± 39
0.63
162 ± 46
147 ± 45
0.22
Malondialdehyde (μmol/l)
1451 ± 748
1359 ± 684
0.65
1646 ± 690
1170 ± 622
0.009
TAC (mmol trolox equiv./L)
0.79 ± 0.53
1.08 ± 0.76
0.12
0.8 ± 0.51
1.0 ± 0.4
0.10
DS, Descurainia sophia; TAC, total antioxidant capacity. value of 0.05 is considered significant. value of <0.01 is considered highly significant.
