Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
Table 3
The comparison of outcomes between pre- and post-DS or placebo for different study groups and period.
Group I (DS administration followed by placebo)
Group II (placebo followed by DS administration)
Study groups
Pre
Post
value
Study groups
Pre
Post
value
Thirst score
DS
8.5 ± 0.9
7.5 ± 0.86
0.004
Placebo
8.3 ± 0.86
8.0 ± 0.67
0.14
Placebo
7.9 ± 0.89
8.1 ± 0.76
0.57
DS
8.1 ± 0.98
6.4 ± 0.54
<0.001
Potassium (mEq/L)
DS
5.59 ± 0.85
5.54 ± 0.64
0.670
Placebo
5.69 ± 0.90
5.32 ± 0.62
0.119
Placebo
5.50 ± 0.62
5.51 ± 0.54
0.920
DS
5.84 ± 0.89
5.32 ± 0.61
0.007
Cholesterol (mg/dl)
DS
162.37 ± 46.70
114.29 ± 31.39
<0.001
Placebo
154.83 ± 49.25
123.34 ± 35.09
0.006
Placebo
149.59 ± 38.92
137.64 ± 39.03
0.091
DS
200.30 ± 102.95
108.00 ± 33.76
0.101
Calcium (mg/dl)
DS
7.85 ± 0.60
7.95 ± 0.78
0.406
Placebo
8.13 ± 0.60
8.37 ± 0.70
0.058
Placebo
7.85 ± 0.78
8.48 ± 0.80
<0.001
DS
8.50 ± 0.00
8.38 ± 0.85
—
Triglycerides (mg/dl)
DS
209.94 ± 129.32
117.96 ± 35.21
<0.001
Placebo
193.40 ± 94.88
147.37 ± 89.25
0.059
Placebo
187.01 ± 104.85
124.81 ± 71.49
<0.001
DS
200.30 ± 102.95
108.00 ± 33.76
<0.001
Na
DS
144.78 ± 6.48
138.07 ± 3.68
<0.001
Placebo
135.83 ± 4.24
134.03 ± 3.63
0.073
Placebo
136.26 ± 2.35
137.84 ± 3.01
<0.001
DS
135.67 ± 3.51
134.10 ± 3.27
0.667
OXLDL
DS
1645.96 ± 690.66
882.44 ± 380.83
<0.001
Placebo
1451.03 ± 748.13
1301.08 ± 875.57
0.466
Placebo
1359.45 ± 683.99
1071.63 ± 631.66
0.004
DS
1170.22 ± 622.63
846.17 ± 429.22
0.021
ANT
DS
0.80 ± 0.52
1.47 ± 0.71
<0.001
Placebo
0.79 ± 0.54
0.62 ± 0.21
0.087
Placebo
1.08 ± 0.77
0.60 ± 0.20
<0.001
DS
0.99 ± 0.41
1.68 ± 0.55
<0.001
Malondialdehyde (μmol/L)
DS
1709 ± 720
882 ± 380
<0.001
Placebo
1695 ± 743
758 ± 295
<0.001
Placebo
927 ± 351
786 ± 350
0.009
DS
851 ± 334
846 ± 429
0.91
TAC (mmol trolox equiv./L)
DS
0.77 ± 0.5
0.91 ± 0.67
0.003
Placebo
0.8 ± 0.55
0.89 ± 0.6
0.24
Placebo
1.07 ± 0.76
0.96 ± 0.58
0.32
DS
1.15 ± 0.8
0.85 ± 0.5
0.09
Values are expressed as means ± SD; the drug-placebo group took the drug at first, while the placebo-DS group received a placebo following DS. The paired t-test was used to compare the outcomes change before and after the DS or placebo in each study group. DS, Descurainia sophia.
