Review Article

Acupuncture and Related Therapies for Chronic Urticaria: A Critical Overview of Systematic Reviews

Table 1

Characteristics of included SRs.

Included studyCountryAgeIncluded study designNo. of studyNo. of patientInterventionComparatorOutcomesAssessment of methodological qualityMeta-analysis conducted?SubgroupSensitivitySafety

Li [24] (2009)ChinaAge ≥ 12 years oldRCT12984Acupuncture therapy or combined with conventional medicineConventional medicine(2)
(3)
(6)
Classified by the Cochrane handbook. The version is not stated and the Jadad scale evaluationYesYesNoYes

Yan [19] (2015)ChinaAny ageRCT8755Any acupoint stimulation or combined with other therapyNo treatment/placebo or western medication; same other therapy(1)
(8)
Classified by the Cochrane handbook.
The version is not stated
YesYesNoYes

Yao [22] (2016)ChinaAny ageRCT6406Acupuncture or combined with another active therapyNo treatment/placebo/sham acupuncture/other same active therapies(1)
(2)
(3)
(9)
Classified by the Cochrane handbook.
The version is not stated
YesNoNoYes

Liang [41] (2016)ChinaAny ageRCT151554Autohemotherapy or combined with an antihistamine or other treatmentAntihistamine or acupuncture(1)
(2)
(3)
(7)
Classified by the Cochrane handbook.
The version is not stated
YesYesNoYes

Chen [33] (2016)ChinaAny ageRCT5545AutohemotherapyOther therapies except for Autohemotherapy(4)Classified by the Cochrane handbook.
The version is not stated
YesNoNoNo

An [38] (2016)ChinaAny ageRCT12988AutohemotherapyOther therapies except for autohemotherapy(1)
(3)
Jadad scale evaluationYesYesYesNo

Luo [39] (2016)ChinaAny ageRCT8937Autohemotherapy or combined with other therapiesOther therapies(1)
(3)
(4)
Cochrane 5.0.1 and Jadad scale evaluationYesYesYesYes

Liu [35] (2017)ChinaAny ageRCT/CCT6515AutohemotherapyConventional western therapy(4)Jadad scale evaluationYesNoNoNo

Pu [28] (2017)ChinaAny ageRCT10686Autohemotherapy or combined with antihistaminesAntihistamine or acupuncture therapy(2)
(3)
(4)
Cochrane 5.0.1YesNoNoYes

Zhang [31] (2018)ChinaAny ageRCT9751Acupoint embedding or combined with other therapiesOther therapies except for acupoint embedding(1)
(5)
(6)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesYes

Liang [32] (2018)ChinaAny ageRCT/quasi-RCT/CCT7528Acupoint embedding or combined with other therapiesOther therapies except for acupoint embedding(4)
(6)
Jadad scale evaluationYesNoYesNo

Zhu [21] (2018)ChinaAny ageRCT7624Auriculotherapy or combined with other therapiesWestern medicine(2)
(4) (10)
Cochrane 5.0.1YesNoYesYes

Li [37] (2018)ChinaAny ageRCT141051Autohemotherapy or combined with other therapiesOther therapies except for autohemotherapy(1)
(3)
(6)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesYes

Wei [26] (2019)ChinaAny ageRCT12836Acupoint embeddingOther therapies except for acupoint embedding(2)
(3)
(4)
(6)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesYes

Zhao [40] (2019)ChinaAge ≥ 18 years oldRCT161131Acupuncture/electroacupuncture (can be moxibustion, cupping, bleeding, etc.) or combined with the same intervention measures as the control groupWestern medicine(1)
(3)
(6)
(7)
(10)
Classified by the Cochrane handbook.
The version is not stated
YesYesYesYes

Li [36] (2019)ChinaAny ageRCT11763Autohemotherapy combined with other therapiesOther therapies except for autohemotherapy(3)
(6)
Classified by the Cochrane handbook.
The version is not stated
YesNoNoYes

Wu [29] (2019)ChinaAny ageRCT131608Autohemotherapy combined with H1 receptor antagonistsH1 receptor antagonists(1)
(2)
(3)
Cochrane 5.0.1YesYesYesYes

Zhao [30] (2019)ChinaAny ageRCT/CCT12944Autohemotherapy combined with acupuncture and other therapiesOther therapies except for autohemotherapy(1)
(2)
(3)
(4)
Cochrane 5.1.0 and Jadad scale evaluationYesYesYesYes

Yao [20] (2019)ChinaAny ageRCT7512Bloodletting therapy or combined with other active therapiesNo treatment/placebo/sham bloodletting therapy/other same active therapies(1)
(2)
(11)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesYes

Zhao [27] (2020)ChinaAge ≥ 18 years oldRCT161131Acupuncture or combined with western medicineWestern medicine(1)
(3)
(10)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesNo

Zhang [34] (2020)ChinaAny ageRCT/quasi-RCT161325AcupunctureWestern medicine(1)
(3)
(6)
Jadad scale evaluationYesNoNoNo

Xiao [23] (2020)ChinaAny ageRCT12842Dry/wet cupping or combination with other therapiesOther therapies(1)
(2)
(3)
(8)
Cochrane 5.0.1YesYesNoYes

Ke [25] (2021)ChinaAny ageRCT7510Acupuncture therapy combined with herbal decoctionAntihistamine(1)
(3)
(4)
Classified by the Cochrane handbook.
The version is not stated
YesNoYesYes

Note. Outcomes: (1) total efficiency: according to the severity of clinical symptoms using 4 scores; the total score is the sum of the individual scores. Symptom Score Reducing Index (SSRI)=(total score before treatment-total score after treatment)/total score before treatment×100%; (2) adverse reaction rate; (3) recurrence rate; (4) clinical efficacy rate: the clinical complete recovery is considered to be effective, others are invalid; (5) improvement rate; (6) curing rate; (7) IgE levels; (8) the Dermatology Quality Life Index (DLQI); (9) quality of life score (QoL); (10) total improvement of clinical signs and symptoms; (11) disease activity control.