|
Bioactivity | Species | Experiment/Model | Dosage/Formulation | Result | Reference |
|
Antioxidant | Prosopis laevigata leaves | DPPH | 100 μL sample was mixed with 2900 μL of DPPH solution. | The EC50 for DPPH radical-scavenging capacity by acetone crude extracts was about 3000 ppm. | [2] |
| Prosopis laevigata leaves | Hydroxyl radical scavenging | 100 μL each of deoxy-D-ribose (28 mM), FeCl3 (1 mM), EDTA (1.04 mM), H2O2 (1 mM), and ascorbic acid (1 mM) with 500 μL of diluted sample. | The IC50 for hydroxyl radical-scavenging capacity by acetone crude extracts was about 1588 ppm. | [2] |
|
Cardioprotection | Prosopis laevigata leaves | Inhibition of LDL oxidation | The reactant ingredients consisted of 700 μL of PBS, 100 μL of CuSO4 (0.5 mM), 100 μL of LDL, 100 μL of samples or standards. | Purified extracts from Prosopis can avoid the generation of peroxide radicals from the oxidized LDLs. | [2] |
|
Antihyperglycemic activity | Prosopis laevigata leaves | Angiotensin-converting enzyme (ACE) inhibition | The spectrometric procedure by [80]. | The oligomeric polyphenols in Prosopis can inhibit the angiotensin enzymes I and II. | [2] |
| Prosopis cineraria stem bark | Alloxan-induced hyperglycemia model | Hyperglycemic mice were fed a dose of 300 mg/Kg B W once a day for 1.5 months. | Bodyweight and fasting blood glucose level of mice were decreased, while liver glycogen content developed. | [11] |
|
Analgesic and antipyretic activity | Prosopis cineraria stem bark | Brewer’s yeast-induced hyperpyrexia model in experimental rats | The ethanolic extract was estimated by tail immersion and hot plate method. The aqueous extract was estimated by acetic acid-induced writhing test mode. | The extract of Prosopis displayed analgesic and antipyretic capacity. | [61] |
|
Antitumor activity | Prosopis cineraria leaves and bark | Male Wistar rats | Protective action against induced experimental liver tumors. | The administration of the extract (200 and 400 mg/kg) reduces mitochondrial lipid peroxidation (LPO) and liver weight. | [7] |
|
Anti-inflammatory capacity | Prosopis nigra pods flour | Cyclooxygenase inhibition studies | Prosopis extract inhibits the conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2) by human recombinant cyclooxygenase 2 (COX-2). | 0.66 ± 0.03 μg GAE/mL of P. nigra crude extracts can inhibit 50% enzyme activity (IC50). | [4] |
| P. juliflora bark | Carrageenan- and histamine-induced paw edema in rats. | Inflammation by carrageenan, histamine, and prostaglandins. | Methanol extracts of P. juliflora bark show anti-inflammatory capacity. | [3] |
|
Antibacterial activity | Prosopis cineraria stem bark | Agar well diffusion method | Four Gram-negative bacteria, (E. coli, P. aeruginosa, S. typhi, and K. pneumoniae) are used to estimate the antibacterial activity of Prosopis. | Prosopis cineraria showed antibacterial activity at 250 μg/mL. | [11] |
| Prosopis cineraria leaves | Agar well diffusion method | Three microorganisms Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative), and Candida albicans (fungal pathogen) are used. | Prosopis cineraria display positive reactions against all these microorganisms. | [71] |
|
Anticonvulsant activity | Prosopis cineraria stem bark | Maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions in mice | Protect against hind limb tonic extensions (HLTE) induced by MES and PTZ-induced seizures. | Prosopis cineraria demonstrated anticonvulsant activity at doses of 200 and 400 mg/kg and phenytoin (25 mg/kg). | [11] |
|
Hypolipidemic and antiatherosclerotic efficacy | Prosopis cineraria stem bark | Hyperlipidemic rabbits | Rabbits were fed by high-fat diet and cholesterol powder. | 70% extract of Prosopis cineraria stem bark showed hypolipidemic activity. | [11] |
|
Antihelminthic activity | Prosopis cineraria stem bark | Indian earthworm | Estimation of time of paralysis (p) and time of death (d) of the worm. | The extract at a dose of 160 mg/mL caused paralysis in 25 min and death in 62 min. | [75] |
|
Apoptotic activity | Prosopis cineraria leaves | Breast cancer cell line MCF-7 and noncancerous cell line HBL 100 | Giemsa, ethidium bromide, propidium iodide, and Hoechst are used to stain. | Prosopis cineraria leaves can inhibit the proliferation of MCF-7 breast cancer cells. | [76] |
|
Antidepressant activity | Prosopis cineraria leaves | Forced swim test (FST) | Compared with imipramine (15 mg/kg. p.o.). | Prosopis cineraria leaves show antidepressant activity at doses of 200 mg/kg. | [11] |
|
Anticancer activity | Prosopis farcta aerial parts | Against four human tumor cell lines | HepG-2, HeLa, PC3, and MCF-7. | Extract against MCF-7 cell line (IC50 = 5.6 μg/mL) and HeLa cell line (IC50 = 6.9 μg/mL). | [57] |
|