Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Human liver CYP450 enzyme</td><td class="align_center">Corresponding mouse CYP450 enzymes</td><td class="align_center">Probe substrates</td><td class="align_center">Metabolites</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">CYP1A2</td><td class="align_center">Cyp1A2</td><td class="align_center">Phenacetin</td><td class="align_center">Acetaminophen</td></tr><tr><td class="align_left">CYP2C19</td><td class="align_center">Cyp2C37</td><td class="align_center">Omeprazole</td><td class="align_center">5-hydroxyomeprazole</td></tr><tr><td class="align_left">CYP3A4</td><td class="align_center">Cyp3A11</td><td class="align_center">Testosterone</td><td class="align_center">6<i>β</i>-hydroxytestosterone</td></tr><tr><td class="align_left">CYP2E1</td><td class="align_center">Cyp2E1</td><td class="align_center">Chlorzoxazone</td><td class="align_center">6-hydroxychloroxazone</td></tr><tr><td class="align_left">CYP2C9</td><td class="align_center">CypC11</td><td class="align_center">Tolbutamide</td><td class="align_center">5-hydroxytolbutamide</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Substrates and metabolites of CYP450 enzymes.</div>

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Table 2

Table 2: Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models 

Table 2 | Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models 