Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models

Table 3

Changes in CYP450s and transporter enzymes after oral administration of HQD.

No.	CYP450s and transporter	Model vs. Control		Control HQD-3d		Model HQD-3d vs. Model
		Activity	Expression	V Control		Activity	Expression
				Activity	Expression
1	Cyp1A2	↓	↓	↓	↓	↓	—
2	Cyp2C11	↑	↑	↑	—	↑	—
3	Cyp2C37	↑	↑	↓	↓	↓	↓
4	Cyp2E1	↓	↓	↓	↓	↑	↑
5	Cyp3A11	↑	—	↓	↓	↓	↓
6	BCRP	—	↓	—	↑	—	↑
7	P-gp	—	↓	—	↑	—	—
8	OCT1	—	↑	—	—	—	—
9	OCT2	—	↑	—	—	—	↓
10	MRP1	—	↑	—	—	—	↓
11	MRP2	—	↑	—	—	—	↓

, , compared to the control; , , compared to the model; no obvious trend “—”.