Electroacupuncture Alleviates Visceral Hypersensitivity in IBS-D Rats by Inhibiting EGCs Activity through Regulating BDNF/TrkB Signaling Pathway

Figure 1

Schematic diagram of the mechanism of acupuncture treatment of IBS in rats. Brain-Derived Neurotrophic Factor (BDNF) specifically binds to and thus activates the enteric glial cells (EGCs) surface tyrosine kinase receptor B (TrkB), which in turn activates the phospholipase C (PLC) signaling pathway. Then, the activated signaling pathway upregulates intracellular Ca²⁺ levels with the rapid increase of extracellular Ca²⁺ levels, eventually leading to the activation of EGCs.