Role of Antimicrobial Drug in the Development of Potential Therapeutics

Figure 2

Illustration of the mechanism of action of CRISPR/Cas in a bacterial cell. (a) Entry of genetic material of virus, phage, or plasmid into bacteria. (b) Short segments with genetic information of the invader inserts into CRISPR region. (c) Expression of crRNA in the bacterium. (d) Cleavage of the invading DNA by the formation of a cleavage complex consisting of foreign DNA, crRNA, and Cas9 protein.