Integrated Network Pharmacology and Clinical Study to Reveal the Effects and Mechanisms of Bushen Huoxue Huatan Decoction on Polycystic Ovary Syndrome

Table 2

Information on 20 core targets.

Target	Description	UniProt ID	Degree	Status
STAT3	Signal transducer and activator of transcription 3	P40763	45	Reviewed
JUN	Jun proto-oncogene, AP-1 transcription factor subunit	P05412	43	Reviewed
AKT1	AKT serine/threonine kinase 1	P31749	42	Reviewed
MAPK3	Mitogen-activated protein kinase 3	P27361	42	Reviewed
MAPK1	Mitogen-activated protein kinase 1	P28482	40	Reviewed
TP53	Tumour protein P53	P04637	39	Reviewed
TNF	Tumour necrosis factor	P01375	33	Reviewed
MAPK8	Mitogen-activated protein kinase 8	P45983	31	Reviewed
MAPK14	Mitogen-activated protein kinase 14	Q16539	30	Reviewed
IL-6	Interleukin-6	P05231	29	Reviewed
EGFR	Epidermal growth factor receptor	P00533	28	Reviewed
FOS	Fos proto-oncogene, AP-1 transcription factor subunit	P01100	28	Reviewed
APP	Amyloid beta precursor protein	P05067	27	Reviewed
VEGFA	Vascular endothelial growth factor A	P15692	27	Reviewed
ESR1	Oestrogen receptor 1	P03372	26	Reviewed
CTNNB1	Catenin beta 1	P35222	24	Reviewed
EGF	Epidermal growth factor	P01133	24	Reviewed
CXCL8	C-X-C motif chemokine ligand 8	P10145	22	Reviewed
EDN1	Endothelin 1	P05305	22	Reviewed
MYC	MYC proto-oncogene, BHLH transcription factor	P01106	21	Reviewed