Integrated Network Pharmacology and Clinical Study to Reveal the Effects and Mechanisms of Bushen Huoxue Huatan Decoction on Polycystic Ovary Syndrome
Table 9
Inflammatory cytokines with significantly different INT values between PCOS and healthy women detected by proteome profiler human cytokine array kit ( ± S).
Index
Density INT (mm2)
P-value
PCOS
Health women
Reference spots
20778.8 ± 1593.6
21674.2 ± 2436.9
0.1961
CCL5/RANTES
22124.6 ± 1277.8
25117.3 ± 2715.2
0.0005
CD40 ligand/TNFSF5
17456.6 ± 3125.6
14630.6 ± 4630.7
0.0159
Complement component C5/C5a
14752.9 ± 6610
8783.3 ± 9464.3
0.0143
CXCL1/GROα
7409.8 ± 5930.9
0.0 ± 0.0
0.0000
CXCL12/SDF-1
13251.6 ± 4410.3
10547.8 ± 3355.7
0.0036
IL-1ra/IL-1F3
10950.8 ± 2491.8
0.0 ± 0.0
0.0000
IL-8
12428.8 ± 23671.1
19921.4 ± 33480
0.0374
IL-13
1763.2 ± 2766.3
6372.6 ± 4389.7
0.0044
IL-16
2579.3 ± 3031.3
6000.3 ± 5001.8
0.0203
IL-18/IL-1F4
6950.9 ± 4118.1
16923.0 ± 1831.2
0.0000
MIF
18353.9 ± 2793.1
16376.1 ± 3268.7
0.0340
Serpin E1/PAI-1
18189.9 ± 7078.6
22070.2 ± 1389.7
0.0051
Note.Continuous variables were presented as mean ± SD. Satterthwaite was applied when the P-value for F-test (equality of variance test) was <0.05. A P-value <0.05 was considered to be statistically significant in two-tailed test.
