In Vitro Cercaricidal and Schistosomicidal Activities of the Raffia Wine and Hydroethanolic Extracts of Pedilanthus tithymaloides Linn (Poit). Stem Barks
Table 3
Cytotoxicity profile and selectivity index of Pedilanthus tithymaloides extracts for the cercaricidal and schistosomicidal activities.
Cytotoxicity
Cercaricidal activity
Schistosomicidal activity
Extracts
Concentrations (μg/mL)
Inhibition rates (%)
CI50 (μg/mL)
LC50 (μg/mL)
SI
LC50 (μg/mL)
SI
RwPt
1000
32.27 ± 0.16
>1000
665.14 ± 42.41
>1.50
>2000
<1
500
23.69 ± 0.03
250
18.67 ± 0.57
125
16.24 ± 1.01
62.5
15.67 ± 0.75
31.25
13.65 ± 0.15
15.625
9.03 ± 1.03
HePt
1000
50.17 ± 0.23
983.50±7.75
19.26 ± 1.22
51.06
731.17
1.34
500
36.72 ± 3.51
250
37.10 ± 1.92
125
39.47 ± 0.28
62.5
37.35 ± 1.44
31.25
35.09 ± 1.36
15.625
27.63 ± 0.20
SI: selectivity index. RwPt: raffia wine extract of Pedilanthus tithymaloides stem bark. HePt: hydroethanolic extract of Pedilanthus tithymaloides stem bark.
