Evidence-Based Complementary and Alternative Medicine

Review Article

The Efficacy and Safety of Zhengqing Fengtongning for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Table 1

Characteristics of the included studies.


Author, year	Sample size		Sex (male/female)		Age (years)		Treatment		Treatment cycle	Outcomes
Author, year	EG	CG	EG	CG	EG	CG	EG	CG	Treatment cycle	Outcomes

Lin ZX, 2008 [21]	53	54	15/38	16/38	63.5 ± 8.7	65.7 ± 9.2	ZQFTN 120 mg bid + CG	Diclofenac sodium sustained-release tablets	6 months	TER, AE
Tang C, 2010 [22]	33	30	18/15	16/14	58.5 ± 8.3	59.8 ± 8.1	ZQFTN 60 mg bid + CG	Glucosamine sulfate capsules	6 weeks	TER
Liu YL, 2011 [23]	40	40	19/21	22/18	63 ± 8	62 ± 8	ZQFTN 60 mg tid + CG	Glucosamine hydrochloride capsules	3 months	TER, WOMAC, AE
Zhao HY, 2011 [24]	40	40	-	-	59.975 ± 11.077	61.200 ± 10.649	ZQFTN 120 mg bid + CG	Celecoxib	8 weeks	TER, AE
Xu YX, 2013 [25]	35	35	18/17	17/18	52	53	ZQFTN 60 mg bid	Diacerein capsules	8 weeks	TER, AE
Zhu FX, 2013 [26]	43	43	12//31	13/30	65.17 ± 8.73	64.93 ± 9.12	ZQFTN 60 mg bid	Glucosamine hydrochloride capsules	12 weeks	TER, WOMAC, IL-1β, TNF-α, AE
Zheng CE, 2014 [27]	40	40	11//29	9/31	60.8 ± 6.6	61.2 ± 5.8	ZQFTN 60 mg bid + CG	Glucosamine sulfate capsules	1 months	TER, AE
Liu QY, 2016 [28]	40	40	18/22	15/25	68.15 ± 7.8	65.28 ± 1.20	ZQFTN 60 mg bid	Glucosamine hydrochloride capsules	10 weeks	TER, WOMAC, IL-1β, TNF-α, AE
Wu B, 2017 [29]	52	52	36/16	34/18	62.19 ± 7.20	62.24 ± 7.15	ZQFTN 20 mg tid + CG	Meloxicam	4 weeks	TER, IL-1β, TNF-α, AE
Wang CC, 2017 [30]	45	45	16/29	18/27	49.59 ± 5.70	51.63 ± 5.12	ZQFTN 120 mg bid + CG	Sodium hyaluronate injection	10 weeks	VAS, TNF-α, AE
Luo HC, 2018 [31]	60	60	21/39	25/35	61.28 ± 10.12	59.97 ± 11.03	ZQFTN 60 mg bid + CG	Diacerein capsules	8 weeks	TER, VAS, WOMAC, AE
Luo HC, 2019 [32]	49	49	13/36	14/35	57.49 ± 10.52	59.92 ± 10.89	ZQFTN 60 mg bid + CG	Glucosamine hydrochloride capsules	12 weeks	TER, IL-1β, TNF-α, AE
Mi ZY, 2019 [33]	50	50	22/28	19/31	62.7 ± 5.3	60.9 ± 5.0	ZQFTN 60 mg bid + CG	Diacerein capsules	2 months	TER
Wang GL, 2019 [34]	30	30	16/14	17/13	32.2 ± 8.4	40.5 ± 8.2	ZQFTN 60 mg bid	Diacerein capsules	8 weeks	TER
Zhang Q, 2019 [35]	46	46	18/28	16/30	58.91 ± 5.63	58.72 ± 5.81	ZQFTN 120 mg bid + CG	Diacerein capsules	8 weeks	TER, VAS, AE
Zhang Y, 2019 [36]	40	40	22/18	21/19	52.6 ± 2.5	52.7 ± 2.4	ZQFTN 60 mg bid + CG	Sodium hyaluronate injection	5 weeks	TER, AE
Yang J, 2021 [37]	20	20	14//6	13//7	62.45 ± 4.25	62.50 ± 4.00	ZQFTN 60 mg tid	Glucosamine hydrochloride capsules	10 weeks	TER, AE
Yu Z, 2021 [38]	41	41	23/18	24/17	60.78 ± 8.51	61.42 ± 8.23	ZQFTN 120 mg bid	Diacerein capsules	3 months	TER, VAS, AE

EG: experimental group; CG: control group; -: not mentioned; ZQFTN: Zhengqing Fengtongning release tablets; TER: total effective rate; VAS: Visual Analog Scale; WOMAC: Western Ontario and Mc Master University Osteoarthritis Index; IL-1β: serum IL-1β level; TNF-α: serum TNF-α level; AE: adverse events.