[Retracted] miR-216b-5p Inhibited the Progression of Experimental Optic Neuritis via Downregulating FAS

Figure 4

Overexpression of FAS exacerbated the inflammatory response and optic neuritis, and miR-216b-5p reversed this effect (n = 10). (a) Protein expression was measured by western blot. (b) Demyelination score was analyzed by LFB staining. (c) Axonal loss was evaluated by Bielschowsky’s silver staining. IL-17A (d), IL-6 (e), and TNF-α (f) concentrations were measured by ELISA. . Overexpression of FAS promoted Th17 cell differentiation, and miR-216b-5p reversed this effect in EAE mice.

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