Cryptotanshinone Suppressed Postmenopausal Osteoporosis by Preventing RANKL-Mediated Osteoclastogenesis against Kidney Injury

Figure 1

Effect of CPT on OVX-induced bone microarchitecture. (a) Data from network pharmacology analysis. The rats were randomly divided into four groups (n = 10) and treated as described in the section of Materials and Methods: Sham group, OVX group, and OVX groups intragastrically receiving CPT at 10 and 20 mg/kg/day, respectively. (b) Representative micro-CT images. Femur surfaces were color coded to indicate the local thickness (0–0.800 mm). Characteristics of bone microarchitecture in femur including (c) trabecular separation (Tb.Sp,mm), (d) trabecular thickness (Tb.Th, mm), (e) trabecular number (Tb.N, mm−1), (f) bone mineral density (BMD, g/m3), (g) bone mineral content (BMC, mg), and (h) bone volume fraction(BV/TV%) were detected.