Cryptotanshinone Suppressed Postmenopausal Osteoporosis by Preventing RANKL-Mediated Osteoclastogenesis against Kidney Injury

Figure 4

(a) CPT exhibiting no toxicity to RAW 264.7 and reversed differentiation induced by RANKL. First, RAW 264.7 cells were cultured for toxicology trial with different concentrations of CPT (0, 0.1, 1, 10, and 100 µM). (b) Multinucleated cells with more than five nuclei, which were considered mature osteoclasts, observed under a light microscope after RANKL treatment, and they were suppressed by CPT cotreatment.

(a)

(b)