Antitumor Potential of Sericite Treatment Mediated by Cell Cycle Arrest in Triple-Negative MDA-MB231 Breast Cancer Cells

Figure 3

Sericite suppresses cell proliferation in an MDA-MB231 xenograft mouse model. MDA-MB231 cells were xenotransplanted into mice followed by a 24-day stabilization period, after which sericite was orally administrated daily in two different doses (1 mg/kg or 3 mg/kg) for 12 days. Tumor size was measured daily. (a) The 12-day tumor volume measurements. (b) Photographs of mice bearing tumors and tumors after extraction from the mice. (c) Isolated tumors were stained with H and E for PCNA, CD31, and MMP9. Scale bar, 50 μm. Arrows indicate positive DAB staining. (d) PCNA, CD31, and MMP9 protein expression were detected by immunoblotting. All data are representative of three independent experiments. Data are presented as mean ± SEM of three independent experiments. P < 0.05 vs. sericite-fed mice.

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