Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells

<div>Mechanism of JWYHD activation of BMP signaling pathway and promotion of BMSC osteogenic differentiation. JWYHD activates BMP2 to bind to its receptor, leading to phosphorylation of SMAD1/5/8, while P-SMAD1/5/8 binds to SMAD4 and is transported to the nucleus to jointly regulate the transcription of downstream target genes RUNX2 and OCN.</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells 

Figure 7 | Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells 