Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)

Figure 1

Effect of different concentrations of peimine and peiminine on the viability of A549 cells. (a):N + peimine: normal group (0 μg/mL), normal single groups (25, 50, 100, and 200 μg/mL); M + peimine: model group (0 μg/mL), model single groups (25, 50, 100, and 200 μg/mL); N + peimine + peiminine: normal combination groups (25, 50, 100, 200 μg/mL; M + peimine + peiminine: model combination groups (25, 50, 100, and 200 μg/mL). (b): N + peiminine: normal group (0 μg/mL), normal single groups (25, 50, 100, 200 μg/mL); M + peiminine: model group (0 μg/mL), model single groups (25, 50, 100, and 200 μg/mL); N + peiminine + peimine: normal combination groups (25, 50, 100, and 200 μg/mL); M + peiminine + peimine: model combination groups (25, 50, 100, and 200 μg/mL). The concentrations of peimine and peiminine in the combination groups were as follows: peimine:peiminine = 1 : 1, peimine: 25, 50, 100, and 200 μg/mL and peiminine: 25, 50, 100, and 200 μg/mL ( and mean significant difference compared with the normal group, and means significant difference compared with the model group).

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