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| Included articles | Rat breed | Number of subjects (test/control) | Method of excitation | Interventions | Treatment course | Observation indicators | Literature level |
| Test | Control |
|
| Wang [13] | SD rat | 10/10 | Aerosol inhalation of 1% OVA solution was performed for 20 min, once daily for the first 3 consecutive days and then every other day | Intraperitoneal injection of ligustrazine 80 mg/kg 30 min before excitation | Equal volume of normal saline | 4 weeks | 1, 2 | A |
|
| Wang [14] | SD rat | 8/8 | Aerosol inhalation of 1% OVA solution was performed for 20 min, once daily for the first 3 consecutive days and then every other day | Intraperitoneal injection of ligustrazine 80 mg/kg 30 min before excitation | Equal volume of normal saline | 4 weeks | 3 | B |
|
| Xiang [15] | BALB/c mouse | 10/10 | Aerosol inhalation of 1% OVA solution for 30 min, once daily | Intraperitoneal injection of ligustrazine 80 mg/kg 1 h before excitation | Untreated | 7 days | 1, 2, 3 | A |
|
| Ji [16] | SD rat | 12/12 | Aerosol inhalation of 1% OVA solution for 30 min, once daily | Intraperitoneal injection of ligustrazine 80 mg/kg 30 min before excitation | Equal volume of normal saline | 2 weeks | 1, 2, 3 | A |
|
| Wu [17] | Wistar rat | 6/6 | Aerosol inhalation of 1% OVA solution for 30 min, once daily | Intraperitoneal injection of ligustrazine 5 mg/kg 30 min before excitation | Untreated | 4 weeks | 1, 2 | B |
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| Ye [18] | SD rat | 10/10 | Aerosol inhalation of 1% OVA solution for 20 min, once daily | Intraperitoneal injection of ligustrazine 60 mg/kg 30 min before excitation | Untreated | 7 days | 1, 2, 3 | A |
|
| Liu [19] | Wistar rat | 8/6 | Aerosol inhalation of 1% OVA solution for 30 min, once daily | Intraperitoneal injection of ligustrazine 80 mg/kg 30 min before excitation | Untreated | 4 weeks | 1, 3 | A |
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| Yan [20] | Wistar rat | 10/10 | 10 mg OVA and 20 mg aluminium hydroxide was prepared into 2 ml mixed atomization inhalation for 10 min, once daily | Intraperitoneal injection of ligustrazine 2 mg 1 h before excitation | Untreated | 8 weeks | 1, 2 | A |
|
| Wu [21] | Wistar rat | 6/6 | Aerosol inhalation of 1% OVA solution for 30 min, once daily | Intraperitoneal injection of ligustrazine 5 mg 30 min before excitation | Untreated | 4 weeks | 1, 2, 3 | A |
|
| Shi [22] | BALB/c mouse | 10/10 | 2 mg/ml OVA solution was instilled into the nose | Intraperitoneal injection of ligustrazine 80 mg/kg 30 min before excitation | Untreated | 6 days | 1, 2 | A |
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