Antihypertensive Effects of Aqueous Extract of Ricinodendron heudelotii (Baill.) Pierre (Euphorbiaceae) in Wistar Rat

Table 4

Effect of the aqueous extract of Ricinodendron heudelotii on biochemical parameters.

	Control	Salt + R. heudelotii				Salt + amlodipine
Parameters	–	–	40 mg/kg	20 mg/kg	6 mg/kg	10 mg/kg
CHL (mg/dl)	62.6 ± 2.5	97.4 ± 7.4^c	72.2 ± 1.9	77.4 ± 6.7	76.4 ± 3.5	72.8 ± 4.8
HDL (mg/dl)	25.9 ± 2.2	16.0 ± 1.2^c	17.9 ± 0.7	21.4 ± 0.6	21.9 ± 0.4	21.3 ± 1.2
LDL (mg/dl)	34.8 ± 1.5	61.7 ± 7.8^c	41.9 ± 1.2	43.6 ± 5.1	41.6 ± 2.4	41.3 ± 3.4
Trig (mg/dl)	62.5 ± 2.9	95.2 ± 11.0	65.2 ± 3.9	70.4 ± 4.0	52.9 ± 4.8	64.3 ± 3.9
Prot (mg/dl)	81.4 ± 0.3	74.5 ± 0.3	75.0 ± 0.5	78.3 ± 0.2	81.1 ± 0.2	79.8 ± 0.2
Urea (mmol/l)	4.1 ± 0.4	15.0 ± 6.0^a	5.7 ± 1.5	5.7 ± 1.8	5.8 ± 1.1	6.1 ± 1.0
Crea (mg/dl)	0.5 ± 0.1	1.7 ± 0.1^c	0.9 ± 0.3	1.0 ± 0.0	1.0 ± 0.2	0.6 ± 0.0
ALT (U/l)	28.5 ± 4.3	82.21 ± 5.7^c	47.0 ± 7.5	81.0 ± 19.1^b	14.8 ± 1.9	58.6 ± 14.0
AST (U/l)	61.1 ± 14.6	204.7 ± 9.4^c	58.4 ± 14.0	58.6 ± 12.0	49.2 ± 11.7	56.5 ± 10.8

All values are expressed as mean ± SEM from 5 rats. ^a, ^b, and ^c compared to control and , , and compared to the hypertensive group. CHL, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Pro, total protein; Trig, triglycerides; Crea, creatinine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; R. heudelotii, Ricinodendron heudelotii.