Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway

Figure 3

PDE10A promotes neuroinflammation of HT22 cells post mechanical injury. The expression of TNF-α, IL-1β, IL-6, Bax, Bcl-2, and caspase-3 in HT22 cells were measured by Western blotting (a) and (c). HT22 cells viability was measured by the MTT assay (b). Significant compared to control (). ^##Significant compared to PDE10A inhibitor treatment (^##).

(a)

(b)

(c)