Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway

Figure 6

cAMP/PKA alleviated TBI damage by inhibiting NLPR3. The expression of NLPR3, caspase1, TNF-α, IL-1β, IL-6, Bax, Bcl-2, and caspase-3 in HT22 cells was measured by Western blotting (a–c) and (f). HT22 cells viability was measured by the MTT assay (d). Representative images of the escape track of rats in the Morris water maze test (e). Significant compared to control (). ^##Significant compared to MI/TBI (^##). ^ΔΔSignificant compared to cAMP/PKA activator treatment (^ΔΔ).

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