Sigesbeckia orientalis Extract Ameliorates the Experimental Diabetic Nephropathy by Downregulating the Inflammatory and Oxidative Stress Signaling Pathways

Figure 1

Representative photographs of H&E-stained kidney sections (a) and morphometric analysis of the proportion of the cortex occupied by glomeruli, the glomerular profile size, and tubular injury score (b) from control (CTR), diabetic mellitus (DM), and DM Sigesbeckia orientalis extract (SOE)-administrated (DMRx) mice. Kidney sections from animals in the CTR group revealed no significant histological changes. Extensive alterations after diabetes were induced by a streptozotocin (STZ) injection (DM). The eosinophilic colloid substance (white asterisk) present in dilated renal tubules (black asterisk) was observed in DM kidney sections. A renal tubule is displayed with severe disturbance as condensed tubular cells detached from the basement membrane (black arrow), attenuated brush borders, and caused loss of the intact morphology of the renal tubule. Except for the dilated renal tubules, none of the morphological changes that existed in the DM group was found in renal sections of the SOE group. The lumen of glomerular capillaries was more dilated in mice with DM than in CTR mice. Mice with DM without SOE treatment exhibited a decreased number of renal corpuscles, an enlarged glomerular profile, and an obviously higher injury score. Data are presented as the mean ± SD. vs. the CTR or DMRx group.

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