Research Article
Sigesbeckia orientalis Extract Ameliorates the Experimental Diabetic Nephropathy by Downregulating the Inflammatory and Oxidative Stress Signaling Pathways
Figure 4
Representative photographs show 8-hydroxy-2′-guanosine (8-OHdG) IHC-stained kidney sections from control (CTR), diabetes mellitus (DM), and DM Sigesbeckia orientalis extract (SOE)-administered (DMRx) mice (a) and semiquantitative detection of the 8-OHdG-labeled nucleus number index in each group (b). Hyperglycemic (DM) mice had numerous 8-OHdG-labeled nuclei (black arrows), and the labeling index results demonstrated a significant difference between DM mice and the other groups. Data are presented as the mean ± SD. vs. the CTR or DMRx group.
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