Sigesbeckia orientalis Extract Ameliorates the Experimental Diabetic Nephropathy by Downregulating the Inflammatory and Oxidative Stress Signaling Pathways

Table 1

Body weights (BWs) and blood glucose (BS) levels before the experiment and after being sacrificed of control mice (CTR), mice with streptozotocin-induced diabetes (DM), and DM mice with the Sigesbeckia orientalis extract (SOE) administered at 88 mg/kg/daily by oral gavage for 8 weeks after diabetes was induced (DMRx).

Group	n	Initial BW (g)	Final BW (g)	Initial BS (mg\dl)	Final BS (mg\dl)
CTR	7	21.8 ± 2.4	25.2 ± 1.5	126.0 ± 5.2	120.3 ± 5.5
DM	6	22.3 ± 1.6	22.6 ± 0.5	127.3 ± 5.3	373.9 ± 9.8
DMRx	10	22.8 ± 0.5	23.3 ± 1.0^,#	129.1 ± 7.2	286.5 ± 34.0^,#

Data are presented as the mean ± SD. Significantly different from the control (CTR) group, ; and ^#significantly different from the DM group, .