Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance

Table 4

Hepatic histopathological alterations and lesion scoring in HFFD-induced MS rats.

Item	Definition	Score/code	MS	MS + Res
Steatosis grade	Low- to medium-power evaluation of parenchymal involvement by steatosis
	<5%	0
	5%–33%	1		+
	>33%–66%	2	+
	>66%	3
Location	Predominant distribution pattern
	Zone 3	0
	Zone 1	1
	A zonal	2
	Panacinar	3	+	+
Microvesicular steatosis	Contiguous patches
	Not present	0
	Present	1	+	+
Fibrosis stage	None	0	+	+
Inflammation	Overall assessment of all inflammatory foci
Lobular inflammation	No foci	0
	<2 foci per 200× field	1		+
	2–4 foci per 200× field	2	+
	>4 foci per 200× field	3
Portal inflammation	Assessed from low magnification
	None to minimal	0		+
	Greater than minimal	1	+
Microgranulomas	Small aggregates of macrophages
	Absent	0
	Present	1	+	+
Liver cell injury ballooning	None	0
	Few balloon cells	1
	Many cells/prominent ballooning	2	+	+
Acidophil bodies	None to rare	0	+	+
	Many	1
Pigmented macrophages	None to rare	0	+	+
	Many	1
Megamitochondria	None to rare	0
	Many	1	+	+
Other findings
Mallory’s hyaline	Visible on routine stains
	None to rare	0
	Many	1	+	+
Glycogenated nuclei	Contiguous patches
	None to rare	0	+	+
	Many	1