Antioxidative Stress and Anti-Inflammatory Activity of Fucoidan Nanoparticles against Nephropathy of Streptozotocin-Induced Diabetes in Rats

Figure 5

Photomicrographs of H&E staining of rat kidney tissue. The control group showed normal morphology in the kidney (a). The necrosis (black arrows) is found in the streptozotocin group (b). The treatment of fucoidan nanoparticles with 75 mg/kg BW and 150 mg/kg BW given to rats still indicated the presence of mild necrotic (c, d), while the treatment of nanoparticles of fucoidan 300 mg/kg showed the presence of regeneration in damaged kidney cells (e) (H&E, 400x).

(a)

(b)

(c)

(d)

(e)