Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice

Table 2

Effect of crude hydromethanolic extract and solvent fractions of the leaf of S. nigrum on parasitemia level, % suppression, and mean survival time.

Treatments	Dose	% parasitaemia	% suppression	MST (day)
4% Tween 80	10 ml/kg	26.40 ± 1.36	0.00	6.40 ± 0.24
Chloroquine	25 mg/kg	0.00 ± 0.00	100.00	28.40 ± 0.50^a3
Crude hydromethanolic extract	100 mg/kg	18.30 ± 0.86	30.68^a2b3	7.80 ± 0.37^b3
	200 mg/kg	15.20 ± 0.86	42.42^a3b3	8.00 ± 0.44^b3
	400 mg/kg	13.00 ± 0.70	50.75^a3b3	8.40 ± 0.40^b3
Chloroform fraction	100 mg/kg	15.80 ± 1.24	40.15^a3b3	7.60 ± 0.40^b3
	200 mg/kg	12.20 ± 1.32	53.78^a3b3	7.80 ± 0.37^b3
	400 mg/kg	9.20 ± 1.03	65.15^a3b3	9.00 ± 0.31^b3
Ethyl acetate fraction	100 mg/kg	11.40 ± 2.25	56.81^a3b3	8.20 ± 0.37^b3
	200 mg/kg	9.00 ± 0.65	65.9^a3b3	8.80 ± 0.37^b3
	400 mg/kg	7.70 ± 1.15	70.83^a3b3	10.90 ± 0.40^a1b3

Values are expressed as mean ± SEM; n = 5; a = as compared to the negative control; b = as compared to the positive control; 1 = ; 2 = ; 3 = ; MST = mean survival time.