Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice
Table 2
Effect of crude hydromethanolic extract and solvent fractions of the leaf of S. nigrum on parasitemia level, % suppression, and mean survival time.
Treatments
Dose
% parasitaemia
% suppression
MST (day)
4% Tween 80
10 ml/kg
26.40 ± 1.36
0.00
6.40 ± 0.24
Chloroquine
25 mg/kg
0.00 ± 0.00
100.00
28.40 ± 0.50a3
Crude hydromethanolic extract
100 mg/kg
18.30 ± 0.86
30.68a2b3
7.80 ± 0.37b3
200 mg/kg
15.20 ± 0.86
42.42a3b3
8.00 ± 0.44b3
400 mg/kg
13.00 ± 0.70
50.75a3b3
8.40 ± 0.40b3
Chloroform fraction
100 mg/kg
15.80 ± 1.24
40.15a3b3
7.60 ± 0.40b3
200 mg/kg
12.20 ± 1.32
53.78a3b3
7.80 ± 0.37b3
400 mg/kg
9.20 ± 1.03
65.15a3b3
9.00 ± 0.31b3
Ethyl acetate fraction
100 mg/kg
11.40 ± 2.25
56.81a3b3
8.20 ± 0.37b3
200 mg/kg
9.00 ± 0.65
65.9a3b3
8.80 ± 0.37b3
400 mg/kg
7.70 ± 1.15
70.83a3b3
10.90 ± 0.40a1b3
Values are expressed as mean ± SEM; n = 5; a = as compared to the negative control; b = as compared to the positive control; 1 = ; 2 = ; 3 = ; MST = mean survival time.