Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice

Table 3

Effect of crude hydromethanolic extract and solvent fractions of the leaf of S. nigrum L. on body weight of P. berghei-infected mice in a four-day suppressive test.

Treatments	Dose	Body weight (g)
		D0	D4
4% Tween 80	10 ml/kg	26.32 ± 0.35	24.64 ± 0.42	−6.38
Chloroquine	25 mg/kg	26.60 ± 0.44	26.82 ± 0.26	0.83^a1
Crude hydromethanolic extract	100 mg/kg	26.86 ± 0.86	25.48 ± 0.72	−5.14^b1
	200 mg/kg	25.52 ± 0.79	24.36 ± 0.79	−4.54^b1
	400 mg/kg	27.36 ± 0.82	26.60 ± 1.03	−2.78^b2
Chloroform fraction	100 mg/kg	25.32 ± 0.90	23.87 ± 0.71	−5.73^b1
	200 mg/kg	25.72 ± 0.79	24.54 ± 0.75	−4.59^b1
	400 mg/kg	25.88 ± 0.85	25.12 ± 0.60	−2.94^b2
Ethyl acetate fraction	100 mg/kg	24.74 ± 0.66	23.44 ± 0.75	−5.25^b1
	200 mg/kg	25.96 ± 0.90	24.83 ± 0.66	−4.35^b1
	400 mg/kg	23.46 ± 0.29	23.98 ± 0.52	−2.21^b2

Values are expressed as mean ± SEM; n = 5. a = as compared to the negative control (4% tween- 80 as a vehicle) 10 ml/kg; b = as compared to the positive control (chloroquine 25 mg/kg); 3 = ; 2 = ; 1 = .