Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice

Table 5

Parasitemia level, % suppression, and mean survival time of crude extract and solvent fractions of the leaf of S. nigrum of P. berghei-infected mice in the prophylactic test.

Groups	Dose	% parasitemia	% suppression	MST (day)
4%Tween 80	10 ml/kg	28.24 ± 1.20	0	6.80 ± 0.37
Chloroquine	25 mg/kg	0 ± 0.00	100^a3	28.80 ± 0.58
Crude hydromethanolic extract	100 mg/kg	19.56 ± 0.42	30.73^a1b3	7.4000 ± 0.50^b3
	200 mg/kg	16.12 ± 1.26	42.91^a2b3	8.00 ± 0.70^b3
	400 mg/kg	13.64 ± 0.34	51.7^a3b3	8.60 ± 0.51^b3
Chloroform fraction	100 mg/kg	16.18 ± 0.71	42.7^a2b3	8.40 ± 0.51^b3
	200 mg/kg	13.6 ± 0.79	51.84^a3b3	9.00 ± 0.70^b3
	400 mg/kg	9.28 ± 0.62	67.13^a3b3	10.60 ± 0.51^a1b3
Ethyl acetate fraction	100 mg/kg	16.18 ± 1.43	42.70^a2b3	9.00 ± 0.71^b3
	200 mg/kg	13.24 ± 0.51	53.11^a3b3	9.60 ± 0.51^b3
	400 mg/kg	8.18 ± 0.73	71.03^a3b1	11.00 ± 0.71^a2b1

Values are expressed as mean ± SEM; n = 5. a = as compared to the negative control; b = as compared to the positive control, 1 = ; 2 = ; 3 = .