Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice
Table 5
Parasitemia level, % suppression, and mean survival time of crude extract and solvent fractions of the leaf of S. nigrum of P. berghei-infected mice in the prophylactic test.
Groups
Dose
% parasitemia
% suppression
MST (day)
4%Tween 80
10 ml/kg
28.24 ± 1.20
0
6.80 ± 0.37
Chloroquine
25 mg/kg
0 ± 0.00
100a3
28.80 ± 0.58
Crude hydromethanolic extract
100 mg/kg
19.56 ± 0.42
30.73a1b3
7.4000 ± 0.50b3
200 mg/kg
16.12 ± 1.26
42.91a2b3
8.00 ± 0.70b3
400 mg/kg
13.64 ± 0.34
51.7a3b3
8.60 ± 0.51b3
Chloroform fraction
100 mg/kg
16.18 ± 0.71
42.7a2b3
8.40 ± 0.51b3
200 mg/kg
13.6 ± 0.79
51.84a3b3
9.00 ± 0.70b3
400 mg/kg
9.28 ± 0.62
67.13a3b3
10.60 ± 0.51a1b3
Ethyl acetate fraction
100 mg/kg
16.18 ± 1.43
42.70a2b3
9.00 ± 0.71b3
200 mg/kg
13.24 ± 0.51
53.11a3b3
9.60 ± 0.51b3
400 mg/kg
8.18 ± 0.73
71.03a3b1
11.00 ± 0.71a2b1
Values are expressed as mean ± SEM; n = 5. a = as compared to the negative control; b = as compared to the positive control, 1 = ; 2 = ; 3 = .