Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves of Solanum nigrum L. (Solanaceae) against Plasmodium berghei in Mice

Table 6

Effect of crude hydromethanolic extract and solvent fractions of the leaf of S. nigrum L. on body weight of P. berghei-infected mice in the prophylactic test.

Treatments	Dose	Body weight (g)
		D3	D7	%
4% Tween 80	10 ml/kg	25.10 ± .71	21.92 ± 0.54	−12.67
Chloroquine	25 mg/kg	24.52 ± 0.68	24.96 ± 0.50	1.79^a2
Crude hydro-methanolic extract	100 mg/kg	23.96 ± .50	21.66 ± 0.66	−9.60^b1
	200 mg/kg	26.78 ± 0.53	24.98 ± 0.45	−6.72
	400 mg/kg	25.20 ± 0.57	24.12 ± 0.75	−4.29
Chloroform fraction	100 mg/kg	26.79 ± 0.77	24.41 ± 1.37	−8.88
	200 mg/kg	23.87 ± 0.95	22.04 ± 0.93	−7.67
	400 mg/kg	26.22 ± 0.55	25.16 ± 0.32	−4.02
Ethyl acetate fraction	100 mg/kg	23.96 ± 0.65	22.05 ± 0.72	−7.97
	200 mg/kg	25.44 ± 0.93	23.82 ± 0.67	−6.37
	400 mg/kg	23.84 ± 1.65	23.02 ± 0.62	−3.44^a1

Values are expressed as mean ± SEM; n = 5. a = as compared to the negative control (4% tween- 80 as a vehicle) 10 ml/kg; b = as compared to the positive control (chloroquine 25 mg/kg); 3 = ; 2 = ; 1 = .