Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach

Table 4

Drug targets of IS. (The average degree value is 8.670412, and the average medium is 0.20796.)

Gene	Protein name	Degree	Betweenness centrality
MAPK1	Mitogen-activated protein kinase 1	53	0.126385
SRC	Proto-oncogene tyrosine-protein kinase Src	50	0.052449
PIK3R1		47	0.047873
HRAS	GTPase HRas	44	0.033552
AKT1	Phosphatidylinositol 3-kinase regulatory subunit alpha	40	0.109791
RHOA	Transforming protein RhoA	35	0.047081
RAC1	Ras-related C3 botulinum toxin substrate 1	34	0.0268
HSP90AA1	Heat shock protein HSP 90-alpha	33	0.059285
RXRA	Retinoic acid receptor alpha， RAR-alpha	30	0.067159
FN1	Fibronectin 1	29	0.023024
MAPK8	Mitogen-activated protein kinase 8	29	0.022235
ESR1	Estrogen receptor	28	0.091184
MAPK14	Mitogen-activated protein kinase 14	28	0.058202
NCOA1	Nuclear receptor coactivator 1	27	0.039326
CREBBP	CREB binding protein	26	0.03777
IGF-1	Insulin-like growth factor I	25	0.024056
ALDOA	Fructose-bisphosphate aldolase A	22	0.065989
RAP1A	Ras-related protein Rap-1A	21	0.026304
B2M	Beta-2-microglobulin	19	0.034377
PLG	Plasminogen	19	0.023626
F2	Prothrombin	16	0.028418
ARG1	Arginase-1	16	0.021575
CTSD	Cathepsin D	15	0.037545
PPARA	Peroxisome proliferator-activated receptor alpha	15	0.028961
CDA	Cytidine deaminase	14	0.059555
TYMS	Thymidylate synthase	11	0.037145
NOS3	Nitric oxide synthase 3	11	0.036816
DUT	Deoxyuridine triphosphatase	9	0.057749
NT5M	5′(3′)-Deoxyribonucleotidase, mitochondrial	9	0.048718
G6PD	Glucose-6-phosphate dehydrogenase	9	0.027099